Re: 'Immunothrombotic dysregulation in chagas disease and COVID‑19: a comparative study of anticoagulation'

Autor: Gabriel Mayoral Andrade, Eduardo Pérez-Campos Mayoral, Gabriela Vázquez Martínez, Denis Barritault, Eduardo Pérez-Campos, Laura Pérez-Campos Mayoral, María Teresa Hernández-Huerta, Ruth Martínez Cruz, Edgar Zenteno, Malaquías López Cervantes, Margarito Martínez Cruz, Socorro Pina Canseco, Carlos Alberto Matias Cervantes, Dulce Papy-Garcia, Luis Manuel Sánchez Navarro, Claudia López Sánchez
Rok vydání: 2022
Předmět:
Blood Platelets
0301 basic medicine
Chagas disease
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Trypanosoma cruzi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Clinical Biochemistry
Hyperaggregability
Inflammation
Vascular leakage
Article
Hypercoagulability
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
Chagas Disease
Endothelium
Blood Coagulation
Complement Activation
Molecular Biology
biology
SARS-CoV-2
business.industry
Platelet
Pathogen-Associated Molecular Pattern Molecules
Anticoagulants
COVID-19
Thrombosis
Cell Biology
General Medicine
Platelet Activation
biology.organism_classification
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
Etiology
Heparitin Sulfate
Immunothrombosis
medicine.symptom
business
Zdroj: Molecular and Cellular Biochemistry
ISSN: 1573-4919
0300-8177
DOI: 10.1007/s11010-022-04361-z
Popis: Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.
Databáze: OpenAIRE
Externí odkaz: