Glutathione S-transferase influences the fecundity of Schistosoma japonicum
| Autor: | Chun-lian Tang, Ya-wen Zhu, Hong-hua Zhou, Jin Huang, Guo-bo Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Veterinary (miscellaneous) 030231 tropical medicine Biology Schistosoma japonicum Andrology 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine parasitic diseases Parasite hosting Animals RNA Messenger Eggshell Glutathione Transferase Gene knockdown Host (biology) Glutathione 030108 mycology & parasitology Fecundity biology.organism_classification Infectious Diseases Glutathione S-transferase Fertility chemistry Insect Science Schistosomiasis japonica biology.protein Parasitology |
| Zdroj: | Acta tropica. 191 |
| ISSN: | 1873-6254 |
| Popis: | The aim of this study was to investigate the effect of Schistosoma japonicum glutathione S-transferase (SjGST) on the developmental stages of the parasite. We found that the mRNA levels of GST were higher in schistosomula obtained from the host and the eggs than that in other developmental stages. SjGST was mainly distributed in the egg shells, teguments of the worms, and part of the parenchyma of the worms. GST knockdown with RNA interference in S. japonicum worms resulted in a silencing rate higher than 80%. The egg reduction rate (18%) and abnormal egg ratio (28%) were significantly higher (P < 0.05) in the GST-silenced group than in the negative control group. These results indicate that SjGST plays an important role in the fecundity of S. japonicum, specifically in egg formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect