Co-Activation-Based Parcellation of the Lateral Prefrontal Cortex Delineates the Inferior Frontal Junction Area
| Autor: | Margaret T. Lynn, Peter T. Fox, Franz X. Neubert, Marcel Brass, Jan Derrfuss, Simon B. Eickhoff, Paul S. Muhle-Karbe |
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| Rok vydání: | 2015 |
| Předmět: |
Databases
Factual COGNITIVE CONTROL NETWORK computer.software_genre Executive Function Cognition 0302 clinical medicine Voxel Cluster Analysis cognitive control 10. No inequality Prefrontal cortex Language prefrontal cortex Brain Mapping SHORT-TERM-MEMORY 05 social sciences FUNCTIONAL CONNECTIVITY Articles Human brain HUMAN BRAIN medicine.anatomical_structure Frontal lobe inferior frontal junction Psychology Cognitive Neuroscience Models Neurological Prefrontal Cortex Posterior parietal cortex 050105 experimental psychology TASK-RELEVANT INFORMATION 03 medical and health sciences Cellular and Molecular Neuroscience WORKING-MEMORY PARIETAL CORTEX Memory medicine Humans 0501 psychology and cognitive sciences ddc:610 Working memory TOP-DOWN MODULATION Biology and Life Sciences Motor control NEUROIMAGING DATA STIMULUS-DRIVEN ATTENTION meta-analysis Neuroscience computer Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Cerebral cortex 26(5), 2225-2241 (2016). doi:10.1093/cercor/bhv073 CEREBRAL CORTEX |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhv073 |
| Popis: | The inferior frontal junction (IFJ) area, a small region in the posterior lateral prefrontal cortex (LPFC), has received increasing interest in recent years due to its central involvement in the control of action, attention, and memory. Yet, both its function and anatomy remain controversial. Here, we employed a meta-analytic parcellation of the left LPFC to show that the IFJ can be isolated based on its specific functional connections. A seed region, oriented along the left inferior frontal sulcus (IFS), was subdivided via cluster analyses of voxel-wise whole-brain co-activation patterns. The ensuing clusters were characterized by their unique connections, the functional profiles of associated experiments, and an independent topic mapping approach. A cluster at the posterior end of the IFS matched previous descriptions of the IFJ in location and extent and could be distinguished from a more caudal cluster involved in motor control, a more ventral cluster involved in linguistic processing, and 3 more rostral clusters involved in other aspects of cognitive control. Overall, our findings highlight that the IFJ constitutes a core functional unit within the frontal lobe and delineate its borders. Implications for the IFJ’s role in human cognition and the organizational principles of the frontal lobe are discussed. |
| Databáze: | OpenAIRE |
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