Mom doesn’t care: When increased brain CRF system activity leads to maternal neglect in rodents
| Autor: | Oliver J. Bosch, Stefanie M. Klampfl |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system Corticotropin-Releasing Hormone Offspring Rodentia Oxytocin Receptors Corticotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Animals Humans Medicine Maternal Behavior CRF-binding protein Urocortin Maternal neglect Behavior Animal Endocrine and Autonomic Systems business.industry Brain CRF Receptor Medial preoptic area Stria terminalis 030104 developmental biology business Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in Neuroendocrinology. 53:100735 |
| ISSN: | 0091-3022 |
| DOI: | 10.1016/j.yfrne.2019.01.001 |
| Popis: | Mothers are the primary caregivers in mammals, ensuring their offspring's survival. This strongly depends on the adequate expression of maternal behavior, which is the result of a concerted action of "pro-maternal" versus "anti-maternal" neuromodulators such as the oxytocin and corticotropin-releasing factor (CRF) systems, respectively. When essential peripartum adaptations fail, the CRF system has negative physiological, emotional and behavioral consequences for both mother and offspring often resulting in maternal neglect. Here, we provide an elaborate and unprecedented review on the implications of the CRF system in the maternal brain. Studies in rodents have advanced our understanding of the specific roles of brain regions such as the limbic bed nucleus of the stria terminalis, medial preoptic area and lateral septum even in a CRF receptor subtype-specific manner. Furthermore, we discuss potential interactions of the CRF system with other neurotransmitters like oxytocin and noradrenaline, and present valuable translational aspects of the recent research. |
| Databáze: | OpenAIRE |
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