Positive urinary cytology in patients with lung cancer in the absence of obvious urine tract metastases
| Autor: | Voulgaris, E., Pentheroudakis, George, Pappa, L., Bafa, M., Goussia, Anna, Dalezis, P., Tsombanidou, C., Geromichalos, G., Papageorgiou, A., Koutsilieris, M., Malamou-Mitsi, Vassiliki D., Pavlidis, Nicholas |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961], Pentheroudakis, George [0000-0002-6632-2462] |
| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology Lung Neoplasms Mouse medicine.medical_treatment Receptors CXCR4/metabolism Cancer cell Treatment response Mice Cxcr4 Breast cancer 80 and over Disease course Aged 80 and over Chemokine receptor cxcr4 Correlation analysis Tumor localization Secondary lymphoid tissue chemokine Urologic neoplasms Inbred c57bl Lung cancer Immunocytochemistry Human Pulmonary and Respiratory Medicine Receptors CXCR4 medicine.medical_specialty Urinary system Inbred balb c Major clinical study Article Lung Neoplasms/metabolism/mortality/pathology/*urine Primary tumor Kidney function Humans Validation process Lung small cell cancer Animal model Small cell lung carcinoma Animal experiment Aged Adrenal metastasis Non-small-cell lung Urine sediment medicine.disease Mice Inbred C57BL Human cell Urine cytology Case-Control Studies Carcinoma Non-Small-Cell Lung/metabolism/mortality/pathology/*urine Protein expression Chemokine CCL21/metabolism Neoplasm Transplantation Cancer Research Urologic Neoplasms/secondary Mammary neoplasms Cancer staging Animal tissue Carcinoma Lewis Lung Lung neoplasms Carcinoma Non-Small-Cell Lung Lewis lung Cytology Receptors Carcinoma Lewis Lung/pathology/urine Tumor volume Overall survival Middle aged Priority journal Mice Inbred BALB C Heterologous Cytokeratin medicine.diagnostic_test Middle Aged medicine.anatomical_structure Lung non small cell cancer Chemokine Female Animal cell Adult Urologic Neoplasms Transplantation Heterologous Histopathology Case-control studies Neoplasm transplantation Urinary tract tumor Pathophysiology Urothelial metastases Experimental Internal medicine medicine Animals Human tissue Mammary Neoplasms Experimental/pathology/urine Neoplasm Staging Platinum Transplantation Chemotherapy Lung Chemokine CCL21 Performance status business.industry Carcinoma Mammary Neoplasms Experimental Nonhuman Small Cell Lung Carcinoma Chemokine ccl21 Neoplasm staging Small Cell Lung Carcinoma/metabolism/mortality/pathology/*urine business Controlled study Occult |
| Zdroj: | Lung Cancer |
| ISSN: | 0169-5002 |
| DOI: | 10.1016/j.lungcan.2010.10.018 |
| Popis: | Purpose: To study the phenomenon of positive urine cytology in patients with lung cancer in the absence of obvious urothelial metastases. Patients and methods: 150 patients with small (SCLC) and non-small cell lung cancer (NSCLC) of all stages and 3 control groups were prospectively studied. Immunocytochemical study (cytokeratins 7-20, TTF1) in all positive urine specimens and chemokine profile (CXCR4, CCL21) study of the primary tumor in selected positive patients was performed. In experimental study, C57Bl/6 BALB/C mice injected with LLC lung and 4T1 mammary cancer cells were used for the detection of positive urine cytology. Results: 11% of patients with NSCLC, 7% of patients with SCLC and none of the control group had positive urine cytology. In NSCLC, metastatic disease and high tumor burden positively correlated (p = 0.01 and 0.03 respectively) with the phenomenon. In SCLC, correlation with extensive disease and multiple metastatic sites (p = 0.02 and 0.04 respectively) was found. No correlation was found in either group with: age, gender, histology, performance status, line of chemotherapy, previous platinum-based chemotherapy, adrenal metastases, renal function, abnormal urinary sediment, response to chemotherapy and overall survival (p = 0.9). Distinctive chemokine expression was identified in positive patients studied and was not observed in negative patients (×2 p = 0.008). In the experimental study, only the LLC lung cancer cells were detected in the urine cytology of mice. Conclusion: This phenomenon, carrying undefined pathophysiological mechanisms, seems to characterize only patients with metastatic/extensive disease and high tumor burden. Further studies are needed to validate our preliminary chemokine expression results. © 2010 Elsevier Ireland Ltd. 73 1 51 58 |
| Databáze: | OpenAIRE |
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