Effects of neonatal adrenalectomy on 5-HT and TRH-Like immunoreactivity in the rat spinal cord
| Autor: | L. Marlier, P. Poulat, Alain Privat, N. Rajaofetra |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Serotonin endocrine system medicine.medical_specialty Superior cervical ganglion medicine.medical_treatment Biology Rats Sprague-Dawley Lesion Internal medicine Image Processing Computer-Assisted medicine Animals Thyrotropin-Releasing Hormone Ganglia Sympathetic General Neuroscience Adrenalectomy Intermediolateral nucleus Spinal cord Immunohistochemistry Rats Autonomic nervous system Endocrinology medicine.anatomical_structure Animals Newborn Spinal Cord Female medicine.symptom Adrenal medulla |
| Zdroj: | Brain Research Bulletin. 30:617-622 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/0361-9230(93)90091-o |
| Popis: | This study investigated the effects of neonatal unilateral adrenalectomy on the serotonin- (5-HT) and thyrotropin-releasing hormone-like immunoreactivities (TRH-LI) in the intermediolateral cell column (IML) of the rat spinal cord where the sympathetic preganglionic neurons innervating the adrenal medulla are located. The density of the innervation was measured by a computer-assisted image analysis. Two weeks after the lesion, only one rat ( 1 3 ) showed a 30% decrease of 5-HT-LI in the ipsilateral IML, although no modifications were observed for TRH-LI. At 1 month, we observed a variable decrease of 19% to 30% for either 5-HT- or TRH-LI in the ipsilateral IML. However, one animal ( 1 3 ) showed nonsignificant modifications. At 3 months, we showed a 17% mean loss of 5-HT-LI and TRH-LI in the ipsilateral IML. However, the decreases of 5-HT-LI and TRH-LI did not always appear similar. These results appear different from those obtained after neonatal removal of the superior cervical ganglion. |
| Databáze: | OpenAIRE |
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