Nondestructive Characterization of Biodegradable Polymer Erosion in Vivo Using Ultrasound Elastography Imaging
| Autor: | Christopher Hernandez, Anna Gawlik, Monika Goss, Haoyan Zhou, Joseph M. Mansour, Agata A. Exner |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Materials science Biomedical Engineering 02 engineering and technology Polymer 021001 nanoscience & nanotechnology Biodegradable polymer Characterization (materials science) Biomaterials 03 medical and health sciences PLGA chemistry.chemical_compound 030104 developmental biology Polymer degradation chemistry Tissue engineering In vivo Drug delivery 0210 nano-technology Biomedical engineering |
| Zdroj: | ACS biomaterials scienceengineering. 2(6) |
| ISSN: | 2373-9878 |
| Popis: | Significant advancements in biodegradable polymeric materials have been made for numerous biomedical applications including tissue engineering, regenerative medicine, and drug delivery. The functions of these polymers within each application often rely on controllable polymer degradation and erosion, yet the process has proven difficult to measure in vivo. Traditional methods for investigating polymer erosion and degradation are destructive, hampering accurate longitudinal measurement of the samples in the same subject. To overcome this limitation, we have utilized ultrasound elastography imaging as a tool to nondestructively measure strain of poly(lactic-co-glycolic acid) (PLGA) phase sensitive in situ forming implants (ISFI), which changes with progressive loss of structural integrity resulting from polymer erosion. Using this tool, we investigated erosion kinetics of implants comprised of three different PLGA molecular weights (18, 34, and 52 kDa) in vitro and in vivo. The in vitro environment was crea... |
| Databáze: | OpenAIRE |
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