Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo
| Autor: | Glenn E. Schafe, Michael W. Swank, Jacek Debiec, Valérie Doyère, Sarina M. Rodrigues |
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| Přispěvatelé: | Department of Psychology, Yale University, Division of Neuroscience, Baylor College of Medicine, W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, Department of Psychiatry, New York University School, Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Yale University [New Haven], Baylor College of Medecine, New York University School of Medicine, NYU System (NYU) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Signal Transduction
MAPK/ERK pathway Male Auditory Pathways Time Factors [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Long-Term Potentiation MESH: Rats Sprague-Dawley MESH: Synapses Rats Sprague-Dawley 0302 clinical medicine Thalamus MESH: Amygdala MESH: Animals Tissue Distribution MESH: Neuronal Plasticity Fear conditioning Enzyme Inhibitors Phosphorylation Extracellular Signal-Regulated MAP Kinases MESH: Extracellular Signal-Regulated MAP Kinases MESH: Thalamus 0303 health sciences Neuronal Plasticity [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior biology Chemistry Kinase MESH: Electric Stimulation [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Long-term potentiation Amygdala Immunohistochemistry MESH: Nitriles Neuropsychology and Physiological Psychology medicine.anatomical_structure MESH: Auditory Pathways MESH: Enzyme Inhibitors Mitogen-activated protein kinase Mitogen-Activated Protein Kinases Signal Transduction MESH: Enzyme Activation MESH: Rats Cognitive Neuroscience MESH: Butadienes 03 medical and health sciences Cellular and Molecular Neuroscience MESH: Long-Term Potentiation Nitriles medicine Butadienes Animals MESH: Tissue Distribution Protein kinase A 030304 developmental biology MESH: Phosphorylation Research MESH: Time Factors MESH: Immunohistochemistry MESH: Mitogen-Activated Protein Kinases MESH: Male Electric Stimulation Rats Enzyme Activation nervous system Synaptic plasticity Synapses biology.protein Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Learn. & Mem. Learn. & Mem., 2008, 15 (2), pp.55-62. ⟨10.1101/lm.746808⟩ Learning and Memory Learning and Memory, Cold Spring Harbor Laboratory Press, 2008, 15 (2), pp.55-62. ⟨10.1101/lm.746808⟩ |
| ISSN: | 1072-0502 |
| DOI: | 10.1101/lm.746808⟩ |
| Popis: | International audience; We have previously shown that the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/ MAPK) is transiently activated in anatomically restricted regions of the lateral amygdala (LA) following Pavlovian fear conditioning and that blockade of ERK/MAPK activation in the LA impairs both fear memory consolidation and long-term potentiation (LTP) in the amygdala, in vitro. The present experiments evaluated the role of the ERK/MAPK signaling cascade in LTP at thalamo-LA input synapses, in vivo. We first show that ERK/MAPK is transiently activated/phosphorylated in the LA at 5 min, but not 15 or 60 min, after high-frequency, but not low-frequency, stimulation of the auditory thalamus. ERK activation induced by LTP-inducing stimulation was anatomically restricted to the same regions of the LA previously shown to exhibit ERK regulation following fear conditioning. We next show that intra-LA infusion of U0126, an inhibitor of ERK/MAPK activation, impairs LTP at thalamo-LA input synapses. Collectively, results demonstrate that ERK/MAPK activation is necessary for synaptic plasticity in anatomically defined regions of the LA, in vivo. |
| Databáze: | OpenAIRE |
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