In vivo high-resolution imaging of the injured rat spinal cord using a 3.0T clinical MR scanner
| Autor: | Beatrice Sandner, Ulrich Bogdahn, Deepu R. Pillai, Matthias F. Mueller, Felix Schlachetzki, Robin M. Heidemann, Norbert Weidner, Gerhard Schuierer |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Thoracic Vertebrae Imaging Three-Dimensional In vivo medicine Animals Radiology Nuclear Medicine and imaging High resolution imaging Spinal cord injury Spinal Cord Injuries medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging Spinal cord medicine.disease Magnetic Resonance Imaging Mr imaging Rats Inbred F344 Rats Disease Models Animal medicine.anatomical_structure Spinal Cord Feasibility Studies Female Radiology business |
| Zdroj: | Journal of Magnetic Resonance Imaging. 29:725-730 |
| ISSN: | 1522-2586 1053-1807 |
| DOI: | 10.1002/jmri.21477 |
| Popis: | To investigate the feasibility of obtaining high-resolution MR images for the detection of pathological changes occurring in the injured rat spinal cord with a routine clinical 3.0T imaging system.Adult female Fischer 344 rats received thoracic spine contusion injuries. In vivo MR imaging was performed on days 1 and 43 postinjury with a clinical head 3.0T imaging system equipped with a dedicated small animal 4-channel phased array spine surface coil using T2-weighted turbo spin-echo and T1-weighted spin-echo sequences.The acquired images provide good spatial resolution allowing reliable gray/white matter differentiation in the intact spinal cord as well as detection of hemorrhage, edema, and cystic degenerative changes in the injured rat spinal cord as confirmed by correlation with structural alterations in histological sections.Results from the present study demonstrate that a routine clinical MR imaging system can be employed for noninvasive analysis of pathological changes occurring in the injured rat spinal cord and thus might represent a more broadly available, powerful tool to monitor the effects of experimental therapeutic interventions in vivo. |
| Databáze: | OpenAIRE |
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