Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer’s Disease
| Autor: | Shigeki Hirano, Hitoshi Shinotoh, Hitoshi Shimada, Tsuneyoshi Ota, Tetsuya Suhara, Makoto Higuchi, Toshiaki Irie, Koichi Sato, Satoshi Kuwabara, Noriko Tanaka, Ming-Rong Zhang, Kiyoshi Fukushi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Late onset Acetates computer.software_genre Correlation Efficacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Piperidines Alzheimer Disease Voxel Internal medicine medicine Humans Carbon Radioisotopes Age of Onset Aged Brain Mapping medicine.diagnostic_test business.industry General Neuroscience Brain General Medicine Middle Aged Acetylcholinesterase Psychiatry and Mental health Clinical Psychology 030104 developmental biology chemistry Positron emission tomography Positron-Emission Tomography Cardiology Cholinergic Female Radiopharmaceuticals Geriatrics and Gerontology Age of onset business computer 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 62:1539-1548 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-170749 |
| Popis: | BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disorder characterized by chronic progressive cognitive decline and displays underlying brain cholinergic dysfunction, providing a rationale for treatment with cholinomimetic medication. The clinical presentations and courses of AD patients may differ by age of onset. OBJECTIVE The objective of the present study was to illustrate the regional differences of brain acetylcholinesterase (AChE) activity as quantified by N-[11C]methylpiperidinyl-4-acetate ([11C]MP4A) and PET using parametric whole brain analysis and clarify those differences as a function of age. METHODS 22 early onset AD (EOAD) with age at onset under 65, the remaining 26 as late onset AD (LOAD), and 16 healthy controls (HC) were enrolled. Voxel-based AChE activity estimation of [11C]MP4A PET images was conducted by arterial input and unconstrained nonlinear least-squares method with subsequent parametrical analyses. Statistical threshold was set as Family Wise Error corrected, p-value |
| Databáze: | OpenAIRE |
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