Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk
| Autor: | Pagona Lagiou, Dimitrios Trichopoulos, Kathryn Edmiston, Mats Lambe, Hoi Pang Low, William C. Strohsnitter, Inkyung Baik, Qin Liu, Kenneth L. Noller, Hans-Olov Adami, Chung-Cheng Hsieh, David Chelmow, Todd M. Savarese |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Risk Cancer Research medicine.medical_specialty Epidemiology Birth weight CD34 Physiology prenatal exposure cancer risk Umbilical cord 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine medicine Humans 030212 general & internal medicine Risk factor Progenitor cell business.industry Infant Newborn birth weight Fetal Blood Hematopoietic Stem Cells ADP-ribosyl Cyclase 1 Blood Cell Count stem cell Haematopoiesis Endocrinology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cord blood Female Stem cell business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6604183 |
| Popis: | We examined the relation with birth weight and umbilical cord blood concentrations of haematopoietic stem and progenitor populations in 288 singleton infants. Across the whole range of birth weight, there was a positive relation between birth weight and CD34+CD38(-) cells, with each 500 g increase in birth weight being associated with a 15.5% higher (95% confidence interval: 1.6-31.3%) cell concentration. CD34+ and CD34+c-kit+ cells had J-shaped relations and CFU-GM cells had a U-shaped relation with birth weight. Among newborns withor=3000 g birth weights, concentrations of these cells increased with birth weight, while those below 3000 g had higher stem cell concentrations than the reference category of 3000-3499 g. Adjustment for cord blood plasma insulin-like growth factor-1 levels weakened the stem and progenitor cell-birth weight associations. The positive associations between birth weight and stem cell measurements for term newborns with a normal-to-high birth weight support the stem cell burden hypothesis of cancer risk. |
| Databáze: | OpenAIRE |
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