Control of epilepsy with a single daily dose of phenytoin sodium
| Autor: | E M Critchley, D A Cocks |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Phenytoin Adolescent medicine.medical_treatment Phenytoin Sodium Epilepsy otorhinolaryngologic diseases medicine Humans Pharmacology (medical) Morning Pharmacology Clinical Trials as Topic business.industry digestive oral and skin physiology medicine.disease Crossover study Total Daily Dose nervous system diseases stomatognathic diseases Anticonvulsant Anesthesia Female Once daily business Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 2:449-453 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1975.tb00555.x |
| Popis: | Fifty-three patients in an epileptic centre have been studied. All were receiving phenytoin and many were also receiving other antoconvulsant drugs. 2. Thirty-six patients took part in a three month cross over study. There was no significant change in the frequency of epileptic seizures or in the late morning serum concentration of phenytoin when the treatemtn was changed from two to three spaced doses of phenytoin sodium/day to a single dose at 12.00 hours. 3. Seventeen patients acted as a control group. They received phenytoin sodium as two or three spaced doses/day throughout the study. There was no significant change in the frequency of epileptic seizures or in the late morning serum concentration of phenytoin between the first and second three month periods of observation. 4. It is concluded that the total daily dose of phenytoin sodium may be given once daily without reduction of the anticonvulsant effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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