Aversion or Salience Signaling by Ventral Tegmental Area Glutamate Neurons
| Autor: | Marisela Morales, David J. Estrin, David H. Root |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Channelrhodopsin Biology Article 03 medical and health sciences Glutamatergic 0302 clinical medicine Cellular neuroscience Dopamine mental disorders medicine lcsh:Science Systems neuroscience Multidisciplinary musculoskeletal neural and ocular physiology fungi Glutamate receptor Ventral tegmental area 030104 developmental biology medicine.anatomical_structure nervous system lcsh:Q Aversive Stimulus Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes medicine.drug |
| Zdroj: | iScience, Vol 2, Iss, Pp 51-62 (2018) iScience |
| ISSN: | 2589-0042 |
| Popis: | SUMMARY Ventral tegmental area (VTA) neurons play roles in reward and aversion. The VTA has, in addition to dopamine neurons, glutamatergic neurons expressing VGluT2. Here, by determining the firing patterns of VTA-VGluT2 neurons expressing channelrhodopsin 2, we identified a major subpopulation of VTA-VGluT2 neurons whose firing rates decreased or were unchanged during sucrose consumption and increased during facial airpuff presentation. We identified a small subpopulation of VTA-VGluT2 neurons whose firing rates increased in response to both rewarding and aversive stimuli. We also found that the changes in firing rate of some VTA-VGluT2 neurons were greater following reward delivery compared with reward omission, whereas others did not differ. We conclude that VTA-VGluT2 neurons are responsive to aversive stimuli, but subpopulations of VTA-VGluT2 neurons are differentially affected by sucrose reward. Reward-responsive subpopulations of VTA-VGluT2 neurons are also divided into those affected by reward expectation alone or the real-time delivery of reward. Graphical abstract |
| Databáze: | OpenAIRE |
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