Specific antiplatelet glycoprotein autoantibodies are associated with the thrombocytopenia of primary antiphospholipid syndrome
| Autor: | Annette Schaeffer, Bertrand Godeau, Patricia Fromont, Jean-Charles Piette, Liliane Intrator, Philippe Bierling |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Blood Platelets Male medicine.drug_class Immunoblotting Enzyme-Linked Immunosorbent Assay Platelet Membrane Glycoproteins Monoclonal antibody Pathogenesis Immunoglobulin Fab Fragments Immunopathology Humans Medicine Platelet Autoantibodies Autoimmune disease chemistry.chemical_classification biology business.industry Autoantibody Hematology Antiphospholipid Syndrome medicine.disease Thrombocytopenia chemistry Antibodies Anticardiolipin Immunoglobulin G Immunology biology.protein Female Antibody business Glycoprotein |
| Zdroj: | British Journal of Haematology. 98:873-879 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1046/j.1365-2141.1997.3063123.x |
| Popis: | Thrombocytopenia is a frequent complication of primary antiphospholipid syndrome (PAPL) and has been attributed to antibodies directed against platelet glycoproteins (Gp) and also to antiphospholipid antibodies. We tested patients with PAPL with and without thrombocytopenia for specific antiplatelet autoantibodies. Platelet autoantibodies were detected by means of platelet immunoassays which included MAIPA with a panel of monoclonal antibodies directed against all the platelet Gps known to be possible targets for platelet autoantibodies. A high prevalence of serum platelet antibodies was found in patients with thrombocytopenia (73%, 11/15 patients) whereas antiplatelet antibody was detected in only one of the 10 control patients (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text