Drug-abbreviated infections and development of immunity against Trichostrongylus colubriformis in sheep
| Autor: | W. Cabaj, W.E. Jonas, B. Rabel, M. Stankiewicz, A. Pernthaner |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Oxfendazole
Antibodies Helminth Sheep Diseases Biology Weight Gain Immune system Antigen Immunity medicine Animals Anthelmintic Arylsulfatases Anthelmintics Sheep Vaccination Trichostrongylosis Eosinophil Alkaline Phosphatase Mucus Intestines Infectious Diseases medicine.anatomical_structure Antigens Helminth Larva Immunology biology.protein Benzimidazoles Parasitology Antibody medicine.drug |
| Zdroj: | International Journal for Parasitology. 26:97-103 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/0020-7519(95)00088-7 |
| Popis: | A protective immune response without liveweight loss can be induced in sheep against T. colubriformis but results depend on the anthelmintic used and duration of immunizing infections. More than 90% protection was achieved in sheep immunized by three 15- or 7-day oxfendozole abbreviated infections or three 21-day nonabbreviated infections. Only 41% protection was induced by 3-day oxfendozole abbreviated infections. Significantly higher worm burden and faecal egg counts were present after challenge in sheep immunized by 7-day levamizole abbreviated infections compared to 7-day oxfendazole abbreviated infection. Liveweight gains of sheep immunized by 15- and 7-day abbreviated infections were not significantly different than non infected controls. Liveweight loss seemed to be associated with high activity of mucus peroxidase and high numbers of eosinophils in the intestinal lumen. High parasite numbers seemed to be associated with low activity of alkaline phosphatase in mucus. Mucus peroxidase, arylsulphatase, larval migration inhibition of mucus, mucus or serum antibody against L 3 excretory/secretory antigen or somatic L 3 , L 4 and adult antigen were not associated with protection. |
| Databáze: | OpenAIRE |
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