Biological Effects and Biodistribution of Bufotenine on Mice
| Autor: | Hugo Vigerelli, Daniel C. Pimenta, Marta M. Antoniazzi, Juliana Mozer Sciani, Maria Andrea Camarano Eula, Luciana Almeida Sato, Carlos Jared |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Serotonin Biodistribution Article Subject lcsh:Medicine Pharmacology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Pharmacokinetics In vivo Animals Medicine Tissue Distribution Kidney General Immunology and Microbiology Bufotenin business.industry lcsh:R Rabies virus General Medicine Effective dose (pharmacology) Pathophysiology 030104 developmental biology medicine.anatomical_structure Female Serotonin Antagonists business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2018/1032638 |
| Popis: | Bufotenine is an alkaloid derived from serotonin, structurally similar to LSD and psilocin. This molecule is able to inhibit the rabies virus infection in in vitro and in vivo models, increasing the survival rate of infected animals. Being a very promising molecule for an incurable disease and because of the fact that there is no consensus regarding its neurological effects, this study aimed to evaluate chronic treatment of bufotenine on behavior, pathophysiology, and pharmacokinetics of mice. Animals were daily treated for 21 consecutive days with 0.63, 1.05, and 2.1 mg/animal/day bufotenine and evaluated by open field test and physiological parameters during all the experiment. After this period, organs were collected for histopathological and biodistribution analysis. Animals treated with bufotenine had mild behavioral alterations compared to the control group, being dose-response relationship. On the other hand, animals showed normal physiological functions and no histological alterations in the organs. With high doses, an inflammatory reaction was observed in the site of injection, but with no cellular damage. The alkaloid could be found in the heart and kidney with all doses and in the lungs and brain with higher doses. These results show that the effective dose, 0.63 mg/day, is safe to be administered in mice, since it did not cause significant effects on the animals’ physiology and on the CNS. Higher doses were well tolerated, causing only mild behavioral effects. Thus, bufotenine might be a drug prototype for rabies treatment, an incurable disease. |
| Databáze: | OpenAIRE |
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