Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction
| Autor: | David W. Wolfe, Michael A. Jacobs, A. Neil Crowson, Andres E. Cruz-Inigo, Henry J Votava, Cynthia M. Magro |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Pathology Histology Skin Neoplasms T cell Biopsy T-Lymphocytes Angiotensin-Converting Enzyme Inhibitors Dermatology Dyscrasia Pathology and Forensic Medicine medicine Atypia Pseudolymphoma Humans Aged Aged 80 and over Granuloma medicine.diagnostic_test business.industry Anatomical pathology Middle Aged medicine.disease Antidepressive Agents Lymphoma Lymphoma T-Cell Cutaneous medicine.anatomical_structure Immunology Interstitial granulomatous drug reaction Anticonvulsants Female Drug Eruptions business Precancerous Conditions |
| Zdroj: | Journal of cutaneous pathology. 37 |
| ISSN: | 1600-0560 |
| Popis: | Background: A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma. Methods: In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn. Results: Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides. Conclusions: We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction Magro CM, Cruz-Inigo AE, Votava H, Jacobs M, Wolfe D, Crowson A N Neil. Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction. |
| Databáze: | OpenAIRE |
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