Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone?
| Autor: | Rania Hanafi, Aglaia Pappa, Georgia-Persephoni Voulgaridou, Vasiliki Malamou-Mitsi, Ioannis Anestopoulos, Alexandros G. Georgakilas, Rodrigo Franco, Dominique Ziech, Mihalis I. Panayiotidis |
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| Rok vydání: | 2012 |
| Předmět: |
DNA damage
Biology medicine.disease_cause Protein oxidation Biochemistry Lipid oxidation Biomarkers Tumor medicine Humans Molecular Biology chemistry.chemical_classification Reactive oxygen species Proteins Cancer General Medicine DNA oxidation medicine.disease Oxidative Stress Cell Transformation Neoplastic chemistry Immunology Cancer research Molecular Medicine Mouth Neoplasms Lipid Peroxidation Reactive Oxygen Species Carcinogenesis Oxidative stress DNA Damage |
| Zdroj: | Current Molecular Medicine. 12:698-703 |
| ISSN: | 1566-5240 |
| DOI: | 10.2174/156652412800792598 |
| Popis: | Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis. |
| Databáze: | OpenAIRE |
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