Liquid-Liquid Immiscibility in Membranes
| Autor: | Harden M. McConnell, Marija Vrljic |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Exothermic reaction
Macromolecular Substances Membrane Fluidity Liquid ordered phase Lipid Bilayers Biophysics Reversible reaction Membrane Microdomains Structural Biology Phase (matter) Monolayer Animals Organic chemistry Colloids Lipid bilayer Phospholipids Phase diagram Chemistry Cell Membrane Membrane Proteins Membranes Artificial Solutions Cholesterol Membrane Chemical engineering lipids (amino acids peptides and proteins) |
| Zdroj: | Annual Review of Biophysics and Biomolecular Structure. 32:469-492 |
| ISSN: | 1545-4266 1056-8700 |
| DOI: | 10.1146/annurev.biophys.32.110601.141704 |
| Popis: | ▪ Abstract The observation of liquid-liquid immiscibility in cholesterol-phospholipid mixtures in monolayers and bilayers has opened a broad field of research into their physical chemistry. Some mixtures exhibit multiple immiscibilities. This unusual property has led to a thermodynamic model of “condensed complexes.” These complexes are the consequence of an exothermic, reversible reaction between cholesterol and phospholipids. In this quantitative model the complexes are sometimes concentrated in a separate liquid phase. The phase separation into a complex-rich phase depends on membrane composition and intensive variables such as temperature. The properties of defined cholesterol-phospholipid mixtures provide a conceptual foundation for the exploration of a number of aspects of the biophysics and biochemistry of animal cell membranes. |
| Databáze: | OpenAIRE |
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