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Introduction: Intestinal fever is very common in Nepal. Multi-drug resistant Salmonella Typhi is popping up all over the world and also in Nepal. Observing the recent pattern of sensitivity will help select the appropriate empirical antibiotics in a resource-constrained country such as Nepal, as cultural facilities are not available nationwide. Material and methods: The study included 86 S. typhi isolates from blood cultures of patients with suspected typhoid fever who came to the clinic or were admitted to Kathmandu Medical College Teaching Hospital, Nepal for one-year duration from April 2019 to April, 2020. Results: A total of 86 S. typhi isolates were studied. The mean age of the study population was 22.06 ± 17.1, with the majority of men 44 (51.2%). All S. typhi isolates were sensitive to Meropenem. The highest resistance was observed to amikacin (62.4%), followed by cotrimoxazole (48.4%) and Amoxiclav (46.5%). S. typhi isolates showed a low level of resistance to ceftriaxone (1.16%), cefuroxime (4.6%), azithromycin (13.9%), levofloxacin (11.6%). Conclusions: Based on the results of this study, it can be indicated that oral forms of cefuroxime, levofloxacin and azithromycin can be used as the first line. Then, if the patient does not respond, Ceftriaxone can be used. Meropeman should be reserved for selected cases. Key words: typhoid fever, multi-drug resistance, Salmonella typhi. |
