Diagnostic dilemma in tuberculous pleural effusion
| Autor: | Shaban Mohamed Ramadan, Somaia A. Eissa, Maha Fathi Mohammed, Mahmoud Mohamed Elbatanouny, Nabila Ibrahim Laz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
lcsh:RC705-779
medicine.medical_specialty Tuberculous effusion business.industry Pleural tuberculosis Group ii Adenosine deaminase (ADA) Para pneumonic effusion Diagnostic dilemma QuantiFERON-TB Gold lcsh:Diseases of the respiratory system Predictive value Gastroenterology 03 medical and health sciences Tuberculous pleural effusions 0302 clinical medicine Tuberculous pleural effusion 030228 respiratory system Effusion Internal medicine medicine Pleural fluid 030212 general & internal medicine business |
| Zdroj: | Egyptian Journal of Chest Disease and Tuberculosis, Vol 66, Iss 2, Pp 327-330 (2017) |
| ISSN: | 0422-7638 |
| Popis: | Aim To evaluate the clinical use of interferon gamma release assays (QuantiFERON-TB Gold (In-Tube Method)) for the diagnosis of pleural tuberculosis and comparing it with ADA as a method for diagnosis TB effusion. Patients and methods 40 patients presenting with pleural effusions were classified according to their final diagnosis in two groups. Group I: Include 20 cases with tuberculous pleural effusions, group II: Control group: 20 cases divided into 2 subgroups: Subgroup11a: para pneumonic pleural effusions: 8 cases, Subgroup11b: malignant pleural effusions: 12 cases. Results Tuberculous pleural effusion showed statistically significantly lower mean age than non-tuberculous effusion. Tuberculous group showed statistically significantly highest mean ADA. This was followed by para pneumonic group then malignant group. ADA showed sensitivity (98%), specificity (55%), diagnostic accuracy (75%), negative predictive value (PV − ) (67.9%) and positive predictive value (PV + ) (91.7%) in diagnosing tuberculous effusion QuantiFERON-TB Gold showed sensitivity 65%, specificity 70%, PPV (68.4%), NPPV (66.7%) and diagnostic accuracy (67.5%) in diagnosing tuberculous effusion. Conclusion It was concluded that ADA measurement in the pleural fluid is an appropriate, fast diagnostic tool for the diagnosis of tuberculous pleural effusion, with higher sensitivity (98%) and diagnostic accuracy (75%). QuantiFERON-TB Gold which is technically more complicated, expensive and has lower sensitivity (65%) and diagnostic accuracy (67.5%) than ADA. |
| Databáze: | OpenAIRE |
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