Static and Dynamic Membrane Properties of Lateral Vestibular Nucleus Neurons in Guinea Pig Brain Stem Slices
| Autor: | Erwin Idoux, Pierre-Paul Vidal, L. E. Moore, Atsuhiko Uno, Victor J. Wilson, Mathieu Beraneck, Nicolas Vibert |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Neurons Vestibular system Potassium Channels Physiology Chemistry Vestibular Nucleus Lateral General Neuroscience Guinea Pigs Medial vestibular nucleus Action Potentials In Vitro Techniques Membrane Potentials Guinea pig Lateral vestibular nucleus Membrane medicine.anatomical_structure Potassium Channel Blockers medicine Animals Female Neuroscience Intracellular Brain Stem |
| Zdroj: | Journal of Neurophysiology. 90:1689-1703 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.00201.2003 |
| Popis: | In vitro intracellular recordings of central vestibular neurons have been restricted so far to the medial vestibular nucleus (MVN). We performed intracellular recordings of large Deiters' neurons in the lateral vestibular nucleus (LVN) to determine their static and dynamic membrane properties, and compare them with those of type A and type B neurons identified in the MVN. Unlike MVN neurons (MVNn), the giant-size LVN neurons (LVNn) form a homogeneous population of cells characterized by sharp spikes, a low-amplitude, biphasic after-hyperpolarization like type B MVNn, but also an A-like rectification like type A MVNn. In accordance with their lower membrane resistance, the sensitivity of LVNn to current injection was lower than that of MVNn over a large range of frequencies. The main difference between LVNn and MVNn was that the Bode plots showing the sensitivity of LVNn as a function of stimulation frequency were flatter than those of MVNn, and displayed a weaker resonance. Furthermore, most LVNn did not show a gradual decrease of their firing rate modulation in the frequency range where it was observed in MVNn. LVNn synchronized their firing with the depolarizing phase of high-frequency sinusoidal current injections. In vivo studies have shown that the MVN would be mainly involved in gaze control, whereas the giant LVNn that project to the spinal cord are involved in the control of posture. We suggest that the difference in the membrane properties of LVNn and MVNn may reflect their specific physiological roles. |
| Databáze: | OpenAIRE |
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