Two Cases of Rocuronium-Induced Anaphylaxis/Anaphylactic Shock Successfully Treated With Sugammadex
| Autor: | Aiji Sato, Mayumi Hashimoto, Yoko Okumura, Masahiro Okuda, Naoko Tachi, Kanenori Kadoi, Jun Harada |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Circulatory collapse
Hemodynamics Case Reports Sugammadex 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology medicine Humans Androstanols Rocuronium Anaphylaxis business.industry 030208 emergency & critical care medicine Perioperative medicine.disease Anesthesiology and Pain Medicine Epinephrine Anesthesia Anaphylactic shock business Neuromuscular Nondepolarizing Agents gamma-Cyclodextrins medicine.drug |
| Zdroj: | Anesthesia Progress. 66:151-155 |
| ISSN: | 1878-7177 0003-3006 |
| DOI: | 10.2344/anpr-66-01-07 |
| Popis: | While anaphylaxis can occur at any time during general anesthesia, 90% of cases occur at induction of anesthesia. As several drugs are administered simultaneously at this time, it is difficult to identify the causative agent. However, it has been found that rocuronium is the most common drug associated with perioperative anaphylaxis. We treated 2 cases of patients who were administered sugammadex for anaphylactic symptoms thought to be caused by rocuronium, after which the anaphylactic symptoms disappeared. One of the most important aspects of treating anaphylactic shock is improving hemodynamics. If signs indicating circulatory collapse are observed, epinephrine should be administered immediately. However, because rocuronium was suspected of being the causative agent, and taking the patients' clinical course over time into consideration, sugammadex was initially administered. As a result, symptoms improved. Therefore, we believe that the administration of sugammadex may be effective for treating anaphylaxis caused by rocuronium and also help in identifying the causative agent. |
| Databáze: | OpenAIRE |
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