Maternal vitamin B12 deficiency detected in expanded newborn screening
| Autor: | Maria Grazia di Girolamo, Laura Ingenito, Giovanna Gallo, Emanuela Scolamiero, R. Pecce, Guglielmo Rosario Domenico Villani, Cristina Di Stefano, Marianna Caterino, Lucia Albano, Ignazio Franzese, Margherita Ruoppolo |
|---|---|
| Přispěvatelé: | E., Scolamiero, Villani, GUGLIELMO ROSARIO DOMENI, L., Ingenito, R., Pecce, L., Albano, Caterino, Marianna, M. G., di Girolamo, C., Di Stefano, I., Franzese, G., Gallo, Ruoppolo, Margherita |
| Rok vydání: | 2014 |
| Předmět: |
Vitamin b
Pediatrics medicine.medical_specialty Homocysteine Urinary system Clinical Biochemistry Methylmalonic acid Physiology chemistry.chemical_compound Folic Acid Neonatal Screening Pregnancy Carnitine medicine Humans Adverse effect Transcobalamins Newborn screening business.industry Infant Newborn Vitamin B 12 Deficiency General Medicine medicine.disease Dried blood spot Pregnancy Complications Vitamin B 12 chemistry Female business Methylmalonic Acid |
| Zdroj: | Clinical Biochemistry. 47:312-317 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2014.08.020 |
| Popis: | Objectives Besides the inherited form, vitamin B 12 deficiency may be due to diet restrictions or abnormal absorption. The spread of newborn screening programs worldwide has pointed out that non-inherited conditions are mainly secondary to a maternal deficiency. The aim of our work was to study seven cases of acquired vitamin B 12 deficiency detected during our newborn screening project. Moreover, we aimed to evaluate vitamin B 12 and related biochemical parameters status on delivering female to verify the consequences on newborns of eventually altered parameters. Design and methods 35,000 newborns were screened; those showing altered propionyl carnitine (C3) underwent second-tier test for methylmalonic acid (MMA) on dried blood spot (DBS). Subsequently, newborns positive to the presence of MMA on DBS and their respective mothers underwent further tests: serum vitamin B 12 , holo-transcobalamin (Holo-TC), folate and homocysteine; newborns were also tested for urinary MMA content. A control study was conducted on 203 females that were tested for the same parameters when admitted to hospital for delivery. Results Approximately 10% of the examined newborns showed altered C3. Among these, seven cases of acquired vitamin B 12 deficiency were identified (70% of the MMA-positive cases). Moreover, our data show a high frequency of vitamin B 12 deficiency in delivering female (approximately 48% of examined pregnants). Conclusions We suggest to monitor vitamin B 12 and Holo-TC until delivery and to reconsider the reference interval of vitamin B 12 for a better identification of cases at risk. Finally, newborns from mothers with low or borderline levels of vitamin B 12 should undergo second-tier test for MMA; in the presence of MMA they should be supplemented with vitamin B 12 to prevent adverse effects related to vitamin B 12 deficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect