Levels of soluble stem cell factor in serum of patients with aplastic anemia
| Autor: | S Yancik, André Tichelli, Bruno Speck, A. Wodnar-Filipowicz, Yolanda Moser, V dalle Carbonare, Catherine Nissen, Alois Gratwohl |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Globulin Anemia Hematopoietic growth factor Immunology Stem cell factor Hematopoietic Cell Growth Factors Biochemistry Bone Marrow Reference Values Internal medicine medicine Humans Prospective Studies Aplastic anemia Child Prospective cohort study Aged Antilymphocyte Serum Bone Marrow Transplantation Stem Cell Factor biology business.industry Anemia Aplastic Cell Biology Hematology Middle Aged medicine.disease Hematopoiesis Haematopoiesis medicine.anatomical_structure Endocrinology biology.protein Female Bone marrow business |
| Zdroj: | Blood. 81:3259-3264 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v81.12.3259.3259 |
| Popis: | Aplastic anemia (AA) is a rare bone marrow (BM) disorder characterized by an unexplained failure of hematopoietic precursors to proliferate. In vitro growth of AA BM cells can be improved by the addition of the hematopoietic growth factor SCF (stem cell factor), which suggests that deficiency of SCF may be one of the underlying causes of the disease. In this study, we measured the concentration of SCF in sera of patients with severe AA. One hundred twenty-eight serum samples from 32 patients, at diagnosis and following therapy, were analyzed. Before treatment, SCF levels varied between 0.33 and 6.1 ng/mL; no correlation between hematopoietic function and SCF serum levels was apparent. Therapy with antilymphocyte globulin (ALG) or bone marrow transplantation (BMT) did not result in a recognizable pattern of changes in SCF levels. However, serum concentration of SCF in many patients with AA was at the low range of control serum levels determined in healthy blood donors. Of 128 AA serum samples tested before and after therapy, 107 were below the mean normal value of 3.3 ng/mL, including 26 samples below the minimum normal value of 1.3 ng/mL, as estimated in 267 controls. We also found that SCF levels in peripheral blood serum correlate well with factor concentrations in the BM plasma. Clinical observations suggest that higher SCF serum levels are often associated with a better clinical status of the patients in terms of survival and transfusion requirements. The data indicate that a deficient production of soluble SCF may contribute to AA in some patients; thus, suggesting a potential therapeutic benefit of SCF in this disorder. |
| Databáze: | OpenAIRE |
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