Changes in Body Composition Before and After Parkinson's Disease Diagnosis

Autor: Shengfang Song, Zhehui Luo, Chenxi Li, Eleanor M. Simonsick, Eric J. Shiroma, Honglei Chen, Xuemei Huang
Rok vydání: 2021
Předmět:
Zdroj: Movement disorders : official journal of the Movement Disorder SocietyReferences. 36(7)
ISSN: 1531-8257
Popis: BACKGROUND Weight loss is common in Parkinson's disease (PD). However, little is known about when it starts, how PD changes as it progresses, and whether there is a differential loss of lean or fat mass. The objective of this study was to examine how body composition changes before and after PD diagnosis. METHODS In the Health, Aging, and Body Composition study (n = 3075; age range, 70-79 years), body composition was assessed using dual-energy x-ray absorptiometry on an annual or biennial basis from year 1 to year 10. For each PD case each year, we calculated the difference between their actual body composition measures and expected values had they not developed PD. Using linear mixed models with crossed random effects, we further examined the trend of change in body composition measures before and after PD diagnosis. RESULTS A total of 80 PD cases were identified in this cohort. Compared with their expected values, PD cases began to lose total and fat mass about 6-7 years before diagnosis, although the differences were not statistically significant until 3-5 years after diagnosis. The loss was substantial and persistent, with statistically significant trends of loss for total body mass (P = 0.008), fat mass (P = 0.001), and percentage fat (P
Databáze: OpenAIRE
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