Regulatory T cells: Master thieves of the immune system
| Autor: | Ethan M. Shevach, Billur Akkaya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology chemical and pharmacologic phenomena Biology Treg cell T-Lymphocytes Regulatory Article 03 medical and health sciences 0302 clinical medicine Immune system Immunopathology Immune inhibition Immune Tolerance Animals Humans Immune effector Effector Peripheral Tolerance Immunity FOXP3 Peripheral tolerance Forkhead Transcription Factors 030104 developmental biology Cytokines Neuroscience 030215 immunology |
| Zdroj: | Cell Immunol |
| ISSN: | 1090-2163 |
| Popis: | Treg cells are the immune system's in-house combatants against pathological immune activation. Because they are vital to maintenance of peripheral tolerance, it is important to understand how they perform their functions. To this end, various mechanisms have been proposed for Treg-mediated immune inhibition. A major group of mechanisms picture Treg cells as skilled thieves stealing a plethora of molecules that would otherwise promote immune effector functions. This suggests that several million years of evolution have endowed Treg cells with efficient ways to deprive immune effectors of activating stimuli to prevent immunopathology for survival of the host. Although we are still long way from deciphering their complete set of tricks, this review will focus on the types of "crimes" committed by these master thieves in both secondary lymphoid organs and non-lymphoid tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect