The Relationship Between Serum TARC, TSLP and POSTN Levels and Childhood Atopic Dermatitis
| Autor: | Pınar Uysal, Aslıhan Karul, Fatih Birtekocak |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Thymic stromal lymphopoietin
Periostin Severity of Illness Index General Biochemistry Genetics and Molecular Biology Dermatitis Atopic Atopy 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Thymic Stromal Lymphopoietin Severity of illness medicine Humans SCORAD medicine.diagnostic_test business.industry Area under the curve Case-control study Atopic dermatitis medicine.disease body regions 030228 respiratory system Case-Control Studies Immunology Cytokines Chemokine CCL17 Chemokines business Cell Adhesion Molecules |
| Zdroj: | Clinical Laboratory. 63 |
| ISSN: | 1433-6510 |
| Popis: | BACKGROUND The aim of the study is to evaluate the relationship between serum periostin (POSTN), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) levels and disease severity and atopy in children with atopic dermatitis. METHODS Sixty children with atopic dermatitis and 31 healthy controls were included in the study. The disease severity was measured by SCORAD scores. Serum POSTN, TARC, and TSLP levels were measured in all participants. The demographic data were recorded, and skin prick tests were performed to evaluate atopy in children with atopic dermatitis. RESULTS Serum POSTN, TARC, and TSLP levels were higher in children with atopic dermatitis than in healthy children (p = 0.041, p = 0.034, and p < 0.001, respectively). Serum POSTN levels were higher with atopy than without atopy in children with atopic dermatitis (p = 0.047). There was a positive moderate correlation between POSTN and the age and symptom duration in children with atopic dermatitis (r = 0.343, p = 0.007, r = 0.484, and p < 0.0001, respectively). In receiver operating characteristics (ROC) analysis, the area under the curve (AUC) was 0.789 (95% CI (0.694 - 0.883), p < 0.0001) for TSLP and the AUC was 0.636 (95% CI (0.522 - 0.750), p = 0.034) for TARC to predict severe atopic dermatitis. CONCLUSIONS Serum POSTN, TARC, and TSLP were higher in children with atopic dermatitis. Serum TARC and TSLP levels might be used as biomarkers to predict severe atopic dermatitis and serum POSTN to predict atopy and disease chronicity. |
| Databáze: | OpenAIRE |
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