| Autor: |
Yucheng Tian, Kang Liu, Ruoyi Liu, Zhixia Qiu, Yifan Xu, Wei Wei, Xi Xu, Jubo Wang, Hong Ding, Zhiyu Li, Jinlei Bian |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of medicinal chemistry. 65(13) |
| ISSN: |
1520-4804 |
| Popis: |
Ubiquitin-specific protease 8 (USP8), belonging to the deubiquitinase family, has been implicated to be closely related to the occurrence of many malignant tumors, but only a few USP8-targeting inhibitors have been reported to date. In this study, we present virtual screening to discover novel hit candidates that inhibit the catalytic activity of USP8. Exploration of the structure-activity relationship led to the identification of compound |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
