Comparison of Tumor Volume Dependent Mean Diameter with the Longest Diameter and Tumor Volume in Assessing Axillary Lymph Nodes in Breast Cancer
| Autor: | Zülfikar Karabulut, Mehmet Kubat |
|---|---|
| Přispěvatelé: | ALKÜ, 0-belirlenecek |
| Rok vydání: | 2020 |
| Předmět: |
Turkey
Axillary lymph nodes medicine.medical_treatment Lymphatic metastasis Breast Neoplasms Modified Radical Mastectomy Breast cancer medicine Tumor volume Humans Mastectomy Longest Diameter Breast neoplasm business.industry Tumor diameter Lumpectomy Axillary Lymph Node Dissection Tumor burden General Medicine Nomogram medicine.disease Tumor Burden medicine.anatomical_structure Axilla Lymph Node Excision Female Lymph Nodes Nuclear medicine business Volume (compression) |
| Zdroj: | Journal of the College of Physicians and Surgeons Pakistan. 30:595-600 |
| ISSN: | 1681-7168 1022-386X |
| DOI: | 10.29271/jcpsp.2020.06.595 |
| Popis: | Objective To investigate the effectiveness of tumor volume dependent mean diameter (Rmax) in determining axillary lymph node metastasis positivity instead of the largest diameter (Dmax) in breast cancer. Study design Descriptive study. Place and duration of study Department of General Surgery, Ankara Training and Reseach Hospital, Turkey, from January 2009 to December 2018. Methodology Patients with breast cancer, who underwent modified radical mastectomy and lumpectomy and axillary lymph node dissection due to invasive carcinoma, included in this study. Approximate vTm was calculated from the obtained tumor specimen dimensions using ellipsoid volume formula. From the sphere volume formula, Rmax, which gives the same vTm value, was reversely calculated. Efficacy and usability of Rmax value were evaluated on nomograms that are available online; and are used most frequently owing to its ease of use. Results In 305 patients, mean Dmax was 3.4 ±1.8 cm, mean vTm was 17.9 ±35.9 cm3, and mean Rmax was 2.6 ±1.4 cm. For the distinction of ALNM positive and negative patients, Dmax significant [Area Under Curve (AUC) 0.709], Rmax significant [AUC 0.748] and vTm significant [AUC 0.748] efficacy was considered. Conclusion When the relationships of Dmax and vTm with ALNM were compared in breast cancer cases, the efficacy of vTm is higher. It was found that vTm and Rmax can be used instead of Dmax. The relation of Rmax parameter with ALNM was found to be higher. When Rmax was used in nomogram samples, which are currently used in predicting ALNM positivity, it increased nomogram efficacy. Key Words: Breast neoplasm, Tumor burden, Tumor volume, Tumor diameter, Lymphatic metastasis. |
| Databáze: | OpenAIRE |
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