Effect of ovariectomy on intraosseous vascularization and bone remodelling in rats: action of tiludronate
| Autor: | Bernard Mazières, I. Ludot, Michel Laroche, C. Vernhet, A. Barbier, M. Thiechart, G. Viguier |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Ovariectomy Bone resorption Bone and Bones Bone remodeling Rats Sprague-Dawley Internal medicine medicine Animals Bone Resorption Bone mineral Lumbar Vertebrae Diphosphonates Estradiol business.industry Osteoid Anatomy Resorption Capillaries Rats Endocrinology Bone Trabeculae Ovariectomized rat Lumbar spine Female Bone Remodeling business Blood Flow Velocity |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 6(2) |
| ISSN: | 0937-941X |
| Popis: | In order to study the action of tiludronate on the changes in intraosseous vascularization induced by ovariectomy, and to link these effects to those observed in bone remodelling, 30 female Sprague-Dawley rats (age 40 weeks) were studied. Ten rats were sham-operated and treated by vehicle, 10 rats were ovariec-tomized and treated by vehicle, and 10 rats were ovariectomized and treated orally with tiludronate, 0.16 mmol/kg/per day, 3 days a week for 16 weeks, from the day following ovariectomy. The rats were killed after 4 months, and a histomorphometric study and quantification of intraosseous vessels carried out on the sixth lumbar vertebra. The area of the intraosseous sinusoidal capillaries increased after ovariectomy, which also induced a moderate increase in resorption surfaces and osteoid surfaces leading to a decrease of 40% in the trabecular bone volume at the lumbar spine level. This bone mineral loss was completely prevented by tiludronate, which normalized the bone turnover. However, tiludronate was without any effect on intraosseous vascularization. These results indicate that the surface area of the intraosseous sinusoidal capillaries was correlated positively with resorption surfaces and negatively with trabecular bone volume and the number of bone trabeculae. In these experimental conditions, an inhibitor of bone resorption can exert its positive effect on bone mass without normalization of vascularization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink