Prospective trial of radiotherapy for patients 80 years of age or older with squamous cell carcinoma of the thoracic esophagus
| Autor: | Mitsuhiko Kawashima, Takashi Uno, Nobukazu Fuwa, Kenji Nemoto, Mitsumasa Hashimoto, Masato Sugiyama, Yoshikazu Kagami, Hiroshi Ikeda, Hoichi Kato, Masaaki Kataoka, Yoichirio Tamura, Keizo Akuta, Takafumi Toita, Hiroshi Yoshida, Hisao Ito, Kinro Sasaki, Naoto Shikama, Shogo Yamada, Tetsuro Tamamoto, Saeko Hirota |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Cause of Death Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Treatment Failure External beam radiotherapy Stage (cooking) Esophagus Radiation treatment planning Prospective cohort study Neoplasm Staging Proportional Hazards Models Aged 80 and over Radiation Radiotherapy business.industry Radiotherapy Dosage Esophageal cancer medicine.disease Surgery Radiation therapy medicine.anatomical_structure Oncology Multivariate Analysis Carcinoma Squamous Cell Female business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 64:1112-1121 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2005.09.027 |
| Popis: | Purpose: To assess the safety and efficacy of external beam radiotherapy for elderly patients with esophageal cancer. Methods and Materials: A trial testing external beam radiotherapy (66 Gy within 6.5 weeks) as a single-modality treatment was performed for biopsy-proven squamous cell carcinoma of the thoracic esophagus clinically staged as Stage I and IIA (T1–T3N0M0, International Union Against Cancer, 1987) in patients aged ≥80 years. Results: From January 1999 through December 2002, 51 evaluable patients (35 men and 16 women) with a median age of 83 years (range, 80–91 years) were enrolled from 22 institutions. Of the 51 patients, 18 (35%) had Stage T1 and 33 (65%) had Stage T2–T3 disease. Radiotherapy could be completed in 47 patients (92%) within 43–58 days (median, 49). The actuarial incidence of Grade 3 or worse cardiopulmonary complications at 3 years was 26%, with 3 early deaths, and correlated significantly with the size of the anteroposterior radiotherapy portals. The median survival time and overall survival rate at 3 years was 30 months and 39% (95% confidence interval, 25–52%), respectively. Conclusion: The results of high-dose radiotherapy in octogenarians are comparable to those in younger patients, but meticulous treatment planning and quality control is required. |
| Databáze: | OpenAIRE |
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