The Nonsteroidal Antiinflammatory Drug Diclofenac Potentiates the In Vivo Activity of Caspofungin Against Candida albicans Biofilms
| Autor: | Bram Neirinck, Karin Thevissen, Patrick Van Dijck, Anna Bink, Soňa Kucharíková, Jef Vleugels, Bruno P. A. Cammue |
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| Rok vydání: | 2012 |
| Předmět: |
Antifungal Agents
Catheters Diclofenac Drug resistance Pharmacology Microbiology Echinocandins Lipopeptides chemistry.chemical_compound Caspofungin Drug Resistance Fungal In vivo Candida albicans polycyclic compounds medicine Animals Immunology and Allergy skin and connective tissue diseases biology Anti-Inflammatory Agents Non-Steroidal Candidiasis Biofilm Drug Synergism biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Caspofungin Acetate Corpus albicans Rats stomatognathic diseases Infectious Diseases chemistry Biofilms medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 206:1790-1797 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | In this study, we demonstrated that in vitro Candida albicans biofilms grown in the presence of diclofenac showed increased susceptibility to caspofungin. These findings were further confirmed using a catheter-associated biofilm model in rats. C. albicans-inoculated catheters retrieved from rats that were treated with both diclofenac and caspofungin contained significantly fewer biofilm cells and showed no visible biofilms inside the catheter lumens, as documented by scanning electron microscopy, as compared to catheters retrieved from rats receiving only caspofungin or diclofenac. This report indicates that diclofenac could be useful in combination therapy with caspofungin to treat C. albicans biofilm-associated infections. |
| Databáze: | OpenAIRE |
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