Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease
| Autor: | Gustavo Scola, Richard H. Swartz, Pak Cheung Chan, Mario Masellis, Joel Ramirez, Di Yu, Parco Chan, Nathan Herrmann, Fuqiang Gao, Walter Swardfager, Ana Cristina Andreazza, Carmen Ojeda-Lopez, Krista L. Lanctôt, Sandra E. Black, Jacqueline A. Pettersen, Hugo Cogo-Moreira, Demetrios J. Sahlas, Yi Zou, Ángela Milán-Tomás |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Aging Pathology Disease Dinoprost medicine.disease_cause Cohort Studies Lipid peroxidation chemistry.chemical_compound 0302 clinical medicine Risk Factors Hyperlipidemia Aged 80 and over General Neuroscience Middle Aged Magnetic Resonance Imaging White Matter 3. Good health Peripheral medicine.anatomical_structure Hypertension Female Lipid Peroxides medicine.medical_specialty Biology behavioral disciplines and activities White matter 03 medical and health sciences Alzheimer Disease mental disorders medicine Humans Aged Aldehydes Vascular disease medicine.disease Hyperintensity Oxidative Stress Cross-Sectional Studies 030104 developmental biology chemistry Cerebral Small Vessel Diseases Lipid Peroxidation Neurology (clinical) Geriatrics and Gerontology Biomarkers 030217 neurology & neurosurgery Oxidative stress Developmental Biology |
| Zdroj: | Neurobiology of Aging. 59:91-97 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.06.029 |
| Popis: | Subcortical white matter hyperintensities (WMH), presumed to indicate small vessel ischemic vascular disease, are found commonly in elderly individuals with and without Alzheimer's disease (AD). Oxidative stress may instigate or accelerate the development of vascular disease, and oxidative stress markers are elevated in AD. Here, we assess independent relationships between three serum lipid peroxidation markers (lipid hydroperoxides [LPH], 8-isoprostane, and 4-hydroxynonenal) and the presence of extensive subcortical WMH and/or AD. Patients were recruited from memory and stroke prevention clinics into four groups: minimal WMH, extensive WMH, AD with minimal WMH, and AD with extensive WMH. Extensive WMH, but not AD, was associated with higher serum concentrations of 8-isoprostane and LPH. Peripheral LPH concentrations mediated the effect of hypertension on deep, but not periventricular, WMH volumes. 4-hydroxynonenal was associated with hyperlipidemia and cerebral microbleeds, but not with extensive WMH or AD. We conclude that lipid peroxidation mediates hypertensive injury to the deep subcortical white matter and that peripheral blood lipid peroxidation markers indicate subcortical small vessel disease regardless of an AD diagnosis. |
| Databáze: | OpenAIRE |
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