Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma
| Autor: | Ande Satyanarayana, Manali Dimri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway signaling pathway Cancer Research Review lcsh:RC254-282 Receptor tyrosine kinase 03 medical and health sciences 0302 clinical medicine Protein kinase A Protein kinase B PI3K/AKT/mTOR pathway biology Wnt signaling pathway hepatocellular carcinoma targeted therapy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Hedgehog signaling pathway digestive system diseases 3. Good health 030104 developmental biology Oncology 030220 oncology & carcinogenesis biology.protein Cancer research Signal transduction |
| Zdroj: | Cancers, Vol 12, Iss 2, p 491 (2020) Cancers |
| ISSN: | 2072-6694 |
| Popis: | Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at advanced stages with no effective treatment options. With advances in tumor biology and molecular genetic profiling, several different signaling pathways and molecular mechanisms have been identified as responsible for initiating and promoting HCC. Targeting these critical pathways, which include the receptor tyrosine kinase pathways, the Ras mitogen-activated protein kinase (Ras/Raf/MAPK), the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR), the Wnt/β-catenin signaling pathway, the ubiquitin/proteasome degradation and the hedgehog signaling pathway has led to the identification of novel therapeutics for HCC treatment. In this review, we elaborated on our current understanding of the signaling pathways involved in the development and initiation of HCC and anticipate the potential targets for therapeutic drug development. |
| Databáze: | OpenAIRE |
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