Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms
| Autor: | Greg Russell, John H. Stewart, Samuel S. Lentz, Edward A. Levine, E. Nicole Parson, Perry Shen |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Databases Factual Paclitaxel Mitomycin Article Carboplatin Peritoneal Neoplasm chemistry.chemical_compound Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Medicine Humans Infusions Parenteral Peritoneal Neoplasms Aged Ovarian Neoplasms business.industry Mitomycin C General Medicine Hyperthermia Induced Middle Aged medicine.disease Surgery Tumor Debulking chemistry Chemotherapy Cancer Regional Perfusion Cohort Hyperthermic intraperitoneal chemotherapy Female Peritoneum business Ovarian cancer |
| Zdroj: | American journal of surgery. 202(4) |
| ISSN: | 1879-1883 |
| Popis: | Background Few data exist on the treatment of peritoneal surface dissemination (PSD) from ovarian cancer (OC) with hyperthermic intraperitoneal chemotherapy (HIPEC). This work represents a review of the authors' institution's experience with HIPEC for PSD from OC. Methods Fifty-one patients with OC treated with HIPEC between 1996 and 2009 were identified in a prospectively managed database. All patients underwent maximal tumor debulking followed by HIPEC with mitomycin C, carboplatin, or paclitaxel. Results The median survival in this cohort was 29 months. When stratified by resection status, patients undergoing R0 and R1 resections experienced longer median survival than those who underwent R2 resections (47 vs 12 months, P = .0002). Intraoperative blood loss ≤ 400 mL resulted in greater 5-year survival than blood loss > 400 mL (60% vs 15%, P = .025). Conclusions This experience demonstrates that long-term survival is anticipated in patients who undergo complete cytoreduction followed by HIPEC for PSD from OC. These findings not only highlight the potential utility of HIPEC in the treatment of OC but also underscore the importance of maximal cytoreduction followed by HIPEC in this cohort of patients. |
| Databáze: | OpenAIRE |
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