Primary biliary cirrhosis and coronary atherosclerosis: protective antioxidant effect of bilirubin
| Autor: | L. B. Dudnik, M. A. Pokrovskaya, O. A. Azyzova, A. P. Savchenkova, N. P. Solovyova |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Antioxidant Bilirubin medicine.medical_treatment Coronary Artery Disease General Biochemistry Genetics and Molecular Biology Antioxidants Lipid peroxidation chemistry.chemical_compound Blood serum Primary biliary cirrhosis Internal medicine Malondialdehyde medicine Humans In patient Coronary atherosclerosis Aged business.industry Liver Cirrhosis Biliary General Medicine Middle Aged medicine.disease Increased risk Endocrinology chemistry Immunology lipids (amino acids peptides and proteins) Lipid Peroxidation business |
| Zdroj: | Bulletin of experimental biology and medicine. 145(1) |
| ISSN: | 0007-4888 |
| Popis: | Increased concentration of lipid peroxidation products in patients with primary biliary cirrhosis is related to elevation of serum lipid content, but not to activation of lipid peroxidation. Hyperbilirubinemia in patients with primary biliary cirrhosis is accompanied by a decrease in the concentration of lipid peroxidation products and increase in antioxidant activity of blood serum. Antioxidants play a major role in the prevention of atherosclerosis. We hypothesized that the absence of increased risk of atherosclerosis in patients with primary biliary cirrhosis is due to inhibition of lipid peroxidation in blood serum by antioxidant compound bilirubin. |
| Databáze: | OpenAIRE |
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