Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury
Autor: | Julian Dooley, Fanny Dégeilh, Cathy Catroppa, Vicki Anderson, Miriam H. Beauchamp, Carola Tuerk, Michael Kean |
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Přispěvatelé: | Université de Montréal (UdeM), Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], Murdoch Children's Research Institute (MCRI), University of Melbourne, Cuyahoga County Juvenile Court, Dégeilh, Fanny, Centre de recherche du CHU Sainte-Justine [Montreal], CHU Sainte Justine [Montréal]-Université de Montréal (UdeM) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Poison control Audiology [SCCO]Cognitive science 0302 clinical medicine Child Development Injury Severity Score Brain Injuries Traumatic Longitudinal Studies Prefrontal cortex Child Research Articles ComputingMilieux_MISCELLANEOUS Radiological and Ultrasound Technology medicine.diagnostic_test neurodevelopment resting‐state fMRI traumatic brain injury 05 social sciences Magnetic Resonance Imaging Temporal Lobe Neurology Female Anatomy Research Article medicine.medical_specialty Adolescent Traumatic brain injury Prefrontal Cortex RRID: SCR_007037 050105 experimental psychology Temporal lobe Social Skills 03 medical and health sciences Neuroimaging medicine Connectome Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Social Behavior Resting state fMRI Working memory business.industry social brain functional connectivity RRID: SCR_001622 [SCCO] Cognitive science Adolescent Development medicine.disease nervous system RRID: SCR_009550 Neurology (clinical) Nerve Net business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
Zdroj: | Human Brain Mapping Human Brain Mapping, Wiley, 2020, 41 (2), pp.561-576. ⟨10.1002/hbm.24822⟩ |
ISSN: | 1065-9471 1097-0193 |
Popis: | Traumatic brain injury (TBI) in childhood and adolescence can interrupt expected development, compromise the integrity of the social brain network (SBN) and impact social skills. Yet, no study has investigated functional alterations of the SBN following pediatric TBI. This study explored functional connectivity within the SBN following TBI in two independent adolescent samples. First, 14 adolescents with mild complex, moderate or severe TBI and 16 typically developing controls (TDC) underwent resting‐state functional magnetic resonance imaging 12–24 months post‐injury. Region of interest analyses were conducted to compare the groups' functional connectivity using selected SBN seeds. Then, replicative analysis was performed in an independent sample of adolescents with similar characteristics (9 TBI, 9 TDC). Results were adjusted for age, sex, socioeconomic status and total gray matter volume, and corrected for multiple comparisons. Significant between‐group differences were detected for functional connectivity in the dorsomedial prefrontal cortex and left fusiform gyrus, and between the left fusiform gyrus and left superior frontal gyrus, indicating positive functional connectivity for the TBI group (negative for TDC). The replication study revealed group differences in the same direction between the left superior frontal gyrus and right fusiform gyrus. This study indicates that pediatric TBI may alter functional connectivity of the social brain. Frontal‐fusiform connectivity has previously been shown to support affect recognition and changes in the function of this network could relate to more effortful processing and broad social impairments. |
Databáze: | OpenAIRE |
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