Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury

Autor: Julian Dooley, Fanny Dégeilh, Cathy Catroppa, Vicki Anderson, Miriam H. Beauchamp, Carola Tuerk, Michael Kean
Přispěvatelé: Université de Montréal (UdeM), Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], Murdoch Children's Research Institute (MCRI), University of Melbourne, Cuyahoga County Juvenile Court, Dégeilh, Fanny, Centre de recherche du CHU Sainte-Justine [Montreal], CHU Sainte Justine [Montréal]-Université de Montréal (UdeM)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Poison control
Audiology
[SCCO]Cognitive science
0302 clinical medicine
Child Development
Injury Severity Score
Brain Injuries
Traumatic
Longitudinal Studies
Prefrontal cortex
Child
Research Articles
ComputingMilieux_MISCELLANEOUS
Radiological and Ultrasound Technology
medicine.diagnostic_test
neurodevelopment
resting‐state fMRI
traumatic brain injury
05 social sciences
Magnetic Resonance Imaging
Temporal Lobe
Neurology
Female
Anatomy
Research Article
medicine.medical_specialty
Adolescent
Traumatic brain injury
Prefrontal Cortex
RRID: SCR_007037
050105 experimental psychology
Temporal lobe
Social Skills
03 medical and health sciences
Neuroimaging
medicine
Connectome
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Social Behavior
Resting state fMRI
Working memory
business.industry
social brain
functional connectivity
RRID: SCR_001622
[SCCO] Cognitive science
Adolescent Development
medicine.disease
nervous system
RRID: SCR_009550
Neurology (clinical)
Nerve Net
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Zdroj: Human Brain Mapping
Human Brain Mapping, Wiley, 2020, 41 (2), pp.561-576. ⟨10.1002/hbm.24822⟩
ISSN: 1065-9471
1097-0193
Popis: Traumatic brain injury (TBI) in childhood and adolescence can interrupt expected development, compromise the integrity of the social brain network (SBN) and impact social skills. Yet, no study has investigated functional alterations of the SBN following pediatric TBI. This study explored functional connectivity within the SBN following TBI in two independent adolescent samples. First, 14 adolescents with mild complex, moderate or severe TBI and 16 typically developing controls (TDC) underwent resting‐state functional magnetic resonance imaging 12–24 months post‐injury. Region of interest analyses were conducted to compare the groups' functional connectivity using selected SBN seeds. Then, replicative analysis was performed in an independent sample of adolescents with similar characteristics (9 TBI, 9 TDC). Results were adjusted for age, sex, socioeconomic status and total gray matter volume, and corrected for multiple comparisons. Significant between‐group differences were detected for functional connectivity in the dorsomedial prefrontal cortex and left fusiform gyrus, and between the left fusiform gyrus and left superior frontal gyrus, indicating positive functional connectivity for the TBI group (negative for TDC). The replication study revealed group differences in the same direction between the left superior frontal gyrus and right fusiform gyrus. This study indicates that pediatric TBI may alter functional connectivity of the social brain. Frontal‐fusiform connectivity has previously been shown to support affect recognition and changes in the function of this network could relate to more effortful processing and broad social impairments.
Databáze: OpenAIRE
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