Role of hypoxia-mediated cellular prion protein functional change in stem cells and potential application in angiogenesis
| Autor: | Yong Seok Han, Chul Won Yun, Peter Rhee, Seung Pil Yun, Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Angiogenesis medicine.medical_treatment Review tissue regeneration Biology Biochemistry Prion Proteins 03 medical and health sciences angiogenesis Genetics medicine Humans Molecular Biology Protein kinase B Embryonic Stem Cells Neovascularization Pathologic hypoxia anti-oxidant Stem-cell therapy Cell cycle Hypoxia-Inducible Factor 1 alpha Subunit Embryonic stem cell Cell Hypoxia Cell biology Oncogene Protein v-akt cellular prion protein 030104 developmental biology Oncology Gene Expression Regulation STAT protein Cancer research Molecular Medicine Stem cell Signal transduction Signal Transduction |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | Cellular prion protein (PrPC) can replace other pivotal molecules due to its interaction with several partners in performing a variety of important biological functions that may differ between embryonic and mature stem cells. Recent studies have revealed major advances in elucidating the putative role of PrPC in the regulation of stem cells and its application in stem cell therapy. What is special about PrPC is that its expression may be regulated by hypoxia‑inducible factor (HIF)‑1α, which is the transcriptional factor of cellular response to hypoxia. Hypoxic conditions have been known to drive cellular responses that can enhance cell survival, differentiation and angiogenesis through adaptive processes. Our group recently reported hypoxia‑enhanced vascular repair of endothelial colony‑forming cells on ischemic injury. Hypoxia‑induced AKT/signal transducer and activator of transcription 3 phosphorylation eventually increases neovasculogenesis. In stem cell biology, hypoxia promotes the expression of growth factors. According to other studies, aspects of tissue regeneration and cell function are influenced by hypoxia, which serves an essential role in stem cell HIF‑1α signaling. All these data suggest the possibility that hypoxia‑mediated PrPC serves an important role in angiogenesis. Therefore, the present review summarizes the characteristics of PrPC, which is produced by HIF‑1α in hypoxia, as it relates to angiogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|