The Relationships between HIV-1 Infection, History of Methamphetamine Use Disorder, and Soluble Biomarkers in Blood and Cerebrospinal Fluid
| Autor: | T. Jordan Walter, Jennifer Iudicello, Debra Rosario Cookson, Donald Franklin, Bin Tang, Jared W. Young, William Perry, Ronald Ellis, Robert K. Heaton, Igor Grant, Arpi Minassian, Scott Letendre, on behalf of the Translational Methamphetamine AIDS Research Center (TMARC) |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
cognition Male HIV Infections Methamphetamine chemistry.chemical_compound Substance Misuse 0302 clinical medicine Cerebrospinal fluid Medicine 2.1 Biological and endogenous factors Aetiology substance use disorder virus diseases Middle Aged QR1-502 Substance abuse Infectious Diseases Biomarker (medicine) HIV/AIDS biomarker Female medicine.symptom Infection medicine.drug Adult Substance-Related Disorders Inflammation CCL2 Microbiology Article 03 medical and health sciences Immune system Clinical Research Virology Behavioral and Social Science Humans methamphetamine business.industry Prevention HIV Meth medicine.disease Brain Disorders 030104 developmental biology Good Health and Well Being Cross-Sectional Studies chemistry inflammation Immunology HIV-1 immune business Drug Abuse (NIDA only) 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Viruses, Vol 13, Iss 1287, p 1287 (2021) Viruses, vol 13, iss 7 Viruses Volume 13 Issue 7 |
| ISSN: | 1999-4915 |
| Popis: | Methamphetamine (METH) use disorder is highly prevalent among people with HIV (PWH) and is a significant public health problem. HIV and METH use are each associated with immune system dysfunction however, the combined effects on the immune system are poorly understood. This cross-sectional project measured soluble immune biomarkers in plasma and cerebrospinal fluid (CSF) collected from a control group, people with a history of a METH use disorder (METH+), PWH with no history of METH use disorder (HIV+), and PWH with a history of METH use disorder (HIV+/METH+). HIV, METH, and immune dysfunction can also be associated with affective and cognitive deficits, so we characterized mood and cognition in our participants. Two factor analyses were performed for the plasma and CSF biomarkers. Plasma IL-8, Ccl2, VEGF, and 8-isoprostane loaded onto one factor that was highest in the HIV+/METH+ group (p < 0.047) reflecting worse inflammation, vascular injury, and oxidative stress. This plasma factor was also negatively correlated with delayed recall (R = −0.49, p = 0.010), which was worst in the HIV+/METH+ group (p = 0.030 compared to the control group). Overall, these data implicate that combined HIV-1 infection and METH use may exacerbate inflammation, leading to worse cognition. |
| Databáze: | OpenAIRE |
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