Myofibroblasts and inflammatory cells as players of cardiac fibrosis
Autor: | Supachoke Mangmool, Hitoshi Kurose |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Cell signaling Neutrophils Cardiac fibrosis Myocardial Infarction Inflammation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Fibrosis Drug Discovery Leukocytes medicine Extracellular Animals Humans Secretion Myofibroblasts business.industry Organic Chemistry medicine.disease 030104 developmental biology Molecular Medicine Collagen medicine.symptom business Myofibroblast Intracellular |
Zdroj: | Archives of Pharmacal Research. 39:1100-1113 |
ISSN: | 1976-3786 0253-6269 |
Popis: | On myocardial infarction, many cells are injured or died owing to arterial occlusion. Intracellular molecules released from injured or dead cells initiate inflammatory responses that play important roles in cardiac remodeling including fibrosis. Fibrosis is an excess accumulation of extracellular collagen. Currently, drugs used to treat cardiac fibrosis are not commercially available. Myofibroblasts are responsible for the production and secretion of collagen. Infiltrating inflammatory cells interact with fibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities of myofibroblasts. Regulation of collagen production is critical for modulating the progression of fibrosis. Hence, the manipulation of activities of inflammatory cells and myofibroblasts will provide promising therapeutic targets for treatment of cardiac fibrosis. |
Databáze: | OpenAIRE |
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