Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells
| Autor: | Zhanghua Li, Chengjian He, Chao-Chao Yu, Qilin Lu, Aofei Yang, Hao Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Internal medicine
business.industry Osteoporosis Cell Biology Traditional Chinese medicine Review Article medicine.disease Regenerative medicine Bone marrow mesenchymal stem cells chemistry.chemical_compound chemistry Mechanism of action Cancer research Medicine medicine.symptom Bone regeneration business lcsh:RC31-1245 Molecular Biology Icariin Bone mass |
| Zdroj: | Stem Cells International Stem Cells International, Vol 2019 (2019) |
| ISSN: | 1687-9678 1687-966X |
| Popis: | Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is the active ingredient of Herba epimedii, a common herb used in traditional Chinese medicine (TCM) formulations, and can effectively enhance BMSC proliferation and osteogenesis. However, the underlying mechanism of ICA action in BMSCs is not completely clear. In this review, we provide an overview of the studies on the role and mechanism of action of ICA in BMSCs, to provide greater insights into its potential clinical use in bone regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text