Relationships Betweenp16Gene Promoter Methylation and Clinicopathologic Features of Colorectal Cancer: A Meta-Analysis of 27 Cohort Studies
| Autor: | He-Tong Wang, Ying Chen, Dan Liu, Yan-Zhi Chen, Ya Gao, Yu-Xia Zhao |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer Subgroup analysis Biology Bioinformatics Metastasis Internal medicine Biomarkers Tumor Genetics medicine Humans Genetic Predisposition to Disease Stage (cooking) Promoter Regions Genetic Molecular Biology Cyclin-Dependent Kinase Inhibitor p16 Genes p16 Cell Biology General Medicine Odds ratio DNA Methylation medicine.disease Lymphatic Metastasis Meta-analysis DNA methylation Neoplasm Grading Colorectal Neoplasms Cohort study |
| Zdroj: | DNA and Cell Biology. 33:729-738 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2013.2253 |
| Popis: | Many existing studies have demonstrated that p16 promoter methylation might be correlated with the clinicopathologic features of colorectal cancer (CRC), but individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationships between p16 promoter methylation and the clinicopathologic features of CRC. We searched the CISCOM, CINAHL, Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 1, 2013. Meta-analysis was performed using the STATA 12.0 software. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under fixed- or random-effects models. Twenty-seven clinical cohort studies were included with a total of 3311 CRC patients. Our meta-analysis results revealed that p16 promoter methylation was associated with pathological characteristics of CRC (tumor, nodes, metastasis stage: OR=1.55, 95% CI: 1.14-2.13, p=0.006; lymph node metastasis: OR=2.40, 95% CI: 1.37-4.19, p=0.002; histologic grade: OR=2.72, 95% CI: 1.63-4.54, p |
| Databáze: | OpenAIRE |
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