The complete nucleotide sequence of region 1 of the CFA/I fimbria! operon of human enterotoxigenicEscherichia coli
| Autor: | Willshaw Ga, Bart J.A.M. Jordi, van der Zeijst Ba, Wim Gaastra |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
DNA
Bacterial Operon Molecular Sequence Data Biology medicine.disease_cause Biochemistry Enterotoxins Open Reading Frames Endocrinology Plasmid Enterotoxigenic Escherichia coli Escherichia coli Genetics medicine Humans Amino Acid Sequence Codon Molecular Biology Gene Antigens Bacterial Base Composition Base Sequence Structural gene Nucleic acid sequence Molecular biology Fimbriae Bacterial Codon usage bias Fimbriae Proteins |
| Zdroj: | DNA Sequence. 2:257-263 |
| ISSN: | 1042-5179 |
| DOI: | 10.3109/10425179209020811 |
| Popis: | The production of the plasmid-encoded fimbrial antigen CFA/I of enterotoxigenic Escherichia coli requires two DNA regions: CFA/I region 1 and CFA/I region 2. These two regions are separated by about 40 kb on the wildtype plasmid. CFA/I region 1 contains the structural genes, whereas CFA/I region 2 contains a positive regulator. The first two genes (cfaA and cfaB) and the cfaD' sequence of region 1 have already been described. Here the total nucleotide sequence of region 1 is presented. Two new genes in region 1 are described, named cfaC and cfaE. The GC content of the genes in region 1 is 33.6% which is substantially lower than normally found in E. coli genes (50%). The codon usage also differs from the standard codons used in E. coli. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|