The waiting time for prostate cancer treatment in Italy: analysis from the PROS-IT CNR Study
| Autor: | Gacci, M, Greco, I, Artibani, W, Bassi, P, Bertoni, F, Bracarda, S, Briganti, A, Carmignani, G, Carmignani, L, Conti, G, Corvò, R, DE Nunzio, C, Fusco, F, Graziotti, P, Maggi, S, Magrini, S, Mirone, V, Montironi, R, Muto, G, Noale, M, Pecoraro, S, Porreca, A, Ricardi, U, Russi, E, Salonia, A, Simonato, A, Serni, S, Tubaro, A, Zagonel, V, Crepaldi, G, Pros-IT CNR Study Group, D'Angelillo, R |
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| Přispěvatelé: | Gacci, Mauro, Greco, Isabella, Artibani, Walter, Bassi, Pierfrancesco, Bertoni, Filippo, Bracarda, Sergio, Briganti, Alberto, Carmignani, Giorgio, Carmignani, Luca, Conti, Giario, Corvò, Renzo, De Nunzio, Cosimo, Fusco, Ferdinando, Graziotti, Pierpaolo, Maggi, Stefania, Magrini, Stefano M, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Noale, Marianna, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Russi, Elvio, Salonia, Andrea, Simonato, Alchiede, Serni, Sergio, Tubaro, Andrea, Zagonel, Vittorina, Crepaldi, Gaetano |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Waiting time
Male medicine.medical_specialty Waiting Lists Urology Lymph node metastasis Androgen deprivation therapy Settore MED/06 Prostate cancer Percutaneous Coronary Intervention prostate cancer radical prostatectomy screening Quality of life Settore MED/36 Internal medicine medicine Humans Waiting lists Prostatic neoplasms Prostatectomy Radiotherapy Androgens Prostate Quality of Life Prostatic Neoplasms Surgical approach business.industry screening Cancer prostate cancer medicine.disease radical prostatectomy Nephrology T-stage Positive Surgical Margin business |
| Popis: | Background Prostate cancer (PCa) is the second most common neoplasm in male patients. To date, there's no certain indication about the maximum waiting time (WT) acceptable for treatment beginning and the impact on oncological and functional outcomes has not been well established. Methods Data from the National Research Council PCa monitoring multicenter project in Italy (Pros-IT CNR) were prospectively collected and analyzed. WT was defined as the time from the bioptical diagnosis of PCa to the first treatment received. Patients were divided in two groups, using a time frame of 90 days. Quality of life was measured through the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and of the Short-Form Health Survey (SF-12). The occurrence of upgrading, upstaging, presence of lymph node metastasis and positive surgical margins at the final histopathological diagnosis, and PSA at 12 months follow-up were evaluated. Results The overall median WT was 93 days. The logistic multivariable model confirmed that age, being resident in Southern regions of Italy and T staging at diagnosis were significantly associated with a WT >90 days. At 6 months from diagnosis the mean SF-12 score for the emotionalpsychological component was significantly lower in WT ≥ 90 days group (p=0.0428). Among patients treated with surgical approach, no significant differences in oncological outcomes were found in the two groups. Conclusions In our study age, clinical T stage and provenance from Southern regions of Italy are associated with a WT > 90 days. WT might have no impact on functional and oncological outcome. |
| Databáze: | OpenAIRE |
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