Dynamic Changes in Quantitative Features of Human Gastric Lesions
| Autor: | Jean Paul Rigaut, Ventzeslav Enchev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Adenoma
Pathology medicine.medical_specialty Adenomatous polyps Stomach Diseases Human gastric mucosa Chronic gastritis Adenocarcinoma Biology Chronic ulcers lcsh:RC254-282 Polyploidy Karyometry Stomach Neoplasms gastritis ulcers medicine Humans cancer Stomach Ulcer lcsh:QH573-671 Pathological Cell Nucleus lcsh:Cytology morphometry/karyometry DNA DNA Neoplasm Gastric lesions medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Diploidy Cytophotometry digestive system diseases Tissue sections Gastritis Lymphatic Metastasis DNA cytophotometry Other |
| Zdroj: | Analytical Cellular Pathology, Vol 13, Iss 1, Pp 9-16 (1997) Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology |
| ISSN: | 1878-3651 0921-8912 |
| Popis: | Quantitative DNA, morphometric cellular and nuclear variables were evaluated in surgical biopsies from patients with various gastric lesions: chronic gastritis, chronic ulcers, adenomatous polyps (gastric adenomas), primary carcinomas and their corresponding lymph‐node metastases. Paraffin‐embedded tissue sections were studied by static cytophotometry (plug method), karyometry (measurements with a graduated eyepiece micrometer of the major and minor axes of the elliptic nuclear profiles, and calculation of profile areas), and measurements of cellular profiles (largest and smallest caliper diameters). Tissue lymphocytes from the same slide were used as diploid controls for the DNA evaluations.An increase of both cellular and nuclear dimensions and DNA content was noted in all pathological tissues, as compared to normal mucosa; the highest values are found in primary gastric carcinomas. A progressive pattern increase of cellular and nuclear dimensions and of DNA content was observed through normal to cancerous tissues, chronic gastritis, chronic ulcers and adenomatous polyps (adenomas). Lymph‐node metastases, in our study, had smaller nuclear (cellular) dimensions than primary cancers. |
| Databáze: | OpenAIRE |
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