Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder
| Autor: | Ekrem Maloku, Bashkim Kadriu, Roberto Carlos Agis-Balboa, Alessandro Guidotti, John M. Davis, Marin Veldic, Erminio Costa |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
DNA (Cytosine-5-)-Methyltransferase 1 Male Bipolar Disorder DNA-Cytosine Methylases Cell Adhesion Molecules Neuronal Glutamate decarboxylase Caudate nucleus Prefrontal Cortex Nerve Tissue Proteins Medium spiny neuron Methylation Article Basal Ganglia Fluorescence Epigenesis Genetic Cohort Studies Basal ganglia Humans DNA (Cytosine-5-)-Methyltransferases RNA Messenger Reelin Prefrontal cortex In Situ Hybridization gamma-Aminobutyric Acid Biological Psychiatry Aged Aged 80 and over Neurons Extracellular Matrix Proteins Microscopy Confocal biology Putamen Serine Endopeptidases Middle Aged Immunohistochemistry Reelin Protein Psychiatry and Mental health nervous system Schizophrenia biology.protein GABAergic Female Caudate Nucleus Neuroscience |
| Zdroj: | Schizophrenia Research. 91:51-61 |
| ISSN: | 0920-9964 |
| Popis: | In the cerebral prefrontal cortex (PFC), DNA-methyltransferase 1 (DNMT1), the enzyme that catalyzes the methylation of cytosine at carbon atoms in position 5 in CpG dinucleotides, is expressed selectively in GABAergic neurons and is upregulated in layers I and II of schizophrenia (SZ) and bipolar disorder patients with psychosis (BDP). To replicate these earlier findings and to verify whether overexpression of DNMT1 and the consequent epigenetic decrease of reelin and glutamic acid decarboxylase (GAD) 67 mRNA expression also occur in GABAergic medium spiny neurons of the caudate nucleus (CN) and putamen (PT) of SZ and BDP, we studied the entire McLean 66 Cohort (Harvard Brain Tissue Resource Center, McLean Hospital, Belmont, MA) including SZ and BDP, which were matched with nonpsychiatric subjects. The data demonstrate that in GABAergic medium spiny neurons of CN and PT, unlike in GABAergic neurons of layer I and II PFC, the increased expression of DNMT1 and the decrease of reelin and GAD67 occur in SZ but not in BDP. This suggests that different epigenetic mechanisms must exist in the pathogenesis underlying SZ and BDP and implies that these disorders might involve two separate entities that are characterized by a well-defined neuropathology. |
| Databáze: | OpenAIRE |
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