Normal Coding Sequence of Insulin Gene in Pima Indians and Nauruans, Two Groups With Highest Prevalence of Type II Diabetes
| Autor: | Paul Zimmet, Maxine A. Lesniak, Nina Raben, Fabrizio Barbetti, Jesse Roth, Sue W Serjeantson, Stephen Lillioja, Alessandro Cama, Simeon I. Taylor |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Molecular Sequence Data Biology Polymerase Chain Reaction Settore MED/13 - Endocrinologia law.invention chemistry.chemical_compound law Diabetes mellitus Internal medicine Ethnicity Prevalence Internal Medicine medicine Humans Insulin Coding region RNA Messenger Gene Pancreatic hormone Polymerase chain reaction Genetics Polymorphism Genetic Base Sequence Arizona Nucleic acid sequence Exons Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 chemistry Indians North American Female Oligonucleotide Probes DNA Micronesia Proinsulin |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diab.40.1.118 |
| Popis: | The nucleotide sequence of the insulin gene was determined in American Pima Indians and Micronesian Nauruans, two populations in whom the prevalence of non-insulin-dependent (type II) diabetes mellitus is the highest in the world. The insulin gene was amplified by the polymerase chain reaction to generate single-stranded DNA suitable for direct sequencing. The nucleotide sequences of the coding and adjacent regions of the insulin gene in six Pima Indians and two Nauruans with type II diabetes were identical to previously published insulin gene sequences of nondiabetic subjects. |
| Databáze: | OpenAIRE |
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