Epigenetic and genetic landscape of uterine leiomyomas: a current view over a common gynecological disease
| Autor: | Marco Noventa, Antonio Simone Laganà, Onofrio Triolo, Salvatore Giovanni Vitale, Agnese Maria Chiara Rapisarda, Alessandro Favilli, Sandro Gerli, Andrea Tinelli, Valentina Lucia La Rosa, Amerigo Vitagliano, Daniele Vergara |
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| Přispěvatelé: | Laganà, A, Vergara, D, Favilli, A, La Rosa, Vl, Tinelli, A, Gerli, S, Noventa, M, Vitagliano, A, Triolo, O, Rapisarda, Amc, Vitale, Sg. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Fibroblast growth factor
medicine.disease_cause Bioinformatics Cell Transformation Epigenesis Genetic 0302 clinical medicine Epigenetics Genetics Growth factors Myomas Uterine fibroid Uterine leiomyoma Uterine leiomyosarcoma Epidermal growth factor Uterine leiomyosarcoma Progesterone 030219 obstetrics & reproductive medicine Leiomyoma Myometrium Obstetrics and Gynecology General Medicine Cell Transformation Neoplastic 030220 oncology & carcinogenesis Uterine Neoplasms Intercellular Signaling Peptides and Proteins Epigenetics Female Fibroblast Growth Factor 2 Growth factors Myomas medicine.medical_specialty Uterine fibroids medicine.drug_class Uterine leiomyoma Genetics Uterine fibroid 03 medical and health sciences Genetic Internal medicine medicine Humans Neoplastic business.industry Estrogens medicine.disease Human genetics Endocrinology Estrogen business Carcinogenesis Epigenesis |
| Popis: | Purpose: Despite the numerous studies on the factors involved in the genesis and growth of uterine leiomyomas, the pathogenesis of these tumors remains unknown. Intrinsic abnormalities of the myometrium, abnormal myometrial receptors for estrogen, and hormonal changes or altered responses to ischemic damage during the menstrual period may be responsible for the initiation of (epi)genetic changes found in these tumors. Considering these elements, we aimed to offer an overview about epigenetic and genetic landscape of uterine leiomyomas. Methods: Narrative overview, synthesizing the findings of literature retrieved from searches of computerized databases. Results: Several studies showed that leiomyomas have a monoclonal origin. Accumulating evidence converges on the risk factors and mechanisms of tumorigenesis: the translocation t (12;14) and deletion of 7q were found in the highest percentages of recurrence; dysregulation of the HMGA2 gene has been mapped within the critical 12q14-q15 locus. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has been poorly explored. The growth factors with mitogenic activity, such as transforming growth factor-β3, fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I are elevated in fibroids and may have a role as effectors of the tumor promotion. Conclusion: The new clues on genetics and epigenetics, as well as about the growth factors that control normal and pathological myometrial cellular biology may be of great help for the development of new effective and less invasive therapeutic strategies in the near future. |
| Databáze: | OpenAIRE |
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