Is adjunctive open-label zonisamide effective for bipolar disorder?
| Autor: | Megan M. Filkowski, Douglas A. Berv, Arshia A. Shirzadi, Tamara B. Pardo, Jeffry Klugman, S. Nassir Ghaemi |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Adolescent Bipolar disorder not otherwise specified medicine.medical_treatment Zonisamide Severity of Illness Index Antimanic Agents Internal medicine mental disorders medicine Humans Spectrum disorder Bipolar disorder Psychiatry Retrospective Studies Dose-Response Relationship Drug Isoxazoles Middle Aged medicine.disease Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Clinical Psychology Anticonvulsant Mood Mood disorders Anticonvulsants Drug Therapy Combination Female medicine.symptom Psychology Mania medicine.drug |
| Zdroj: | Journal of affective disorders. 105(1-3) |
| ISSN: | 0165-0327 |
| Popis: | Objective To assess the effectiveness and safety of zonisamide in bipolar disorder. Methods A chart review was conducted of naturalistic treatment with zonisamide in 35 outpatients meeting DSM-IV criteria for bipolar disorder (9 males, 26 females; mean +/- SD age = 29.2 +/- 12.7; 14 with bipolar disorder type I, 6 with bipolar disorder type II, and 14 with bipolar disorder not otherwise specified). Patients received zonisamide adjunctive therapy between January 1994 and December 2004. Treatment response was defined as a Clinical Global Impressions - Improvement (CGI-I) scale score of +2 (much improved) or + 3 (very much improved). Results Zonisamide was moderately to markedly effective in 9 subjects (26%). Indication for treatment included depressive (34.3%, [12/35]), manic/hypomanic (28.6%, [10/35]), or mixed (31.4%, [11/35]) symptoms. The mean zonisamide dose was 130 mg/d for a mean duration of treatment of 27.0 +/- 32.3 weeks. Sedation (25%, [4/16]) was the most common side effect; 19/35 (54.3%) reported no side effects. 17/35 (49%) patients terminated early, mostly due to adverse effects (6/35). Using a multivariable model, predictors of response, concurrent mood stabilizers, dose and bipolar subtype (bipolar type I > type II/NOS), were controlled for in this sample. Conclusions In 35 persons with bipolar disorder taking standard mood stabilizers and other psychotropic agents, adjunctive zonisamide appears to have modest benefit in global improvement when added to a pre-existing complex medication regimen in patients with bipolar spectrum disorder. These pilot data support the need for larger studies to test the potential efficacy of zonisamide for treatment in mood disorders. |
| Databáze: | OpenAIRE |
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